課程資訊
課程名稱
 結構生物學概論
Introduction to Structural Biology 
開課學期
 105-1 
授課對象
 生命科學院  生化科技學系  
授課教師
 楊啟伸 
課號
 BST5008 
課程識別碼
 B22 U0180 
班次
  
學分
 2 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期四6,7(13:20~15:10) 
上課地點
 農化二B10 
備註
 系統生物學與生物物理領域課程。先修科目：生物化學或生物化學概論。
總人數上限：80人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1051BST5008_SB 
課程簡介影片
 
核心能力關聯
 本課程尚未建立核心能力關連
課程大綱
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課程概述

This is a class integrates the concepts of structural biology and bioinformatics. The basic principle of amino acids and structre will be explained first, then the modern methods to resolve atomic resolution of protein structures. The relation of protein structure and function will be emphasized in the third part of this class. Bioinformatic principles, methods and modern developments will be followed. 

課程目標
 1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure.
3. Protein structure and function.
4. Software-based analysis of protein sequence.
5. Bioinformatic theories
6. Current developments of bioinformatics methods. 
課程要求
 This class will be taught in English. 
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 待補 
參考書目
 1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA.
3. Materials are updated when new developments occur. 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Mid-term 
30% 
  
2. 
 Final exam 
30% 
 Bioinformatic part could composed of presentation, too. 
3. 
 Presentation 
20% 
  
4. 
 Personal Homework 
20% 
  
 
課程進度
週次
日期
單元主題
第1週
 9/15  Happy Moon Festival!! 
第2週
 9/22  1. Concepts of structural biology
2. Software tools for structural biology 
第3週
 9/27  Amino Acids and Their Structural roles. 
第4週
 10/6  Five different basic structural elements: Alpha helix, Beta sheet, Beta turn, Beta bulge and Loop. 
第5週
 10/13  Five protein structural arrangements. 
第6週
 10/20  1. Protein Functional Domain and Classifications.
2. Motif
3. Protein Conformational Changes  
第7週
 10/27  Resolving protein structures (1) 
第8週
 11/3  Resolving protein structures (2) 
第9週
 11/10  Midterm Exam 
第10週
 11/17  1. Pick your group members
2. Summary of current SB studies
3. Choose the proper methods for your SB study
4. PDB Files Format
 
第11週
 11/24  1) Protein secondary structure & Bioinformatic analysis
2) Protein structure display styles and their usage
 
第12週
 12/1  BYOC (Bring your own computer) day:  
第13週
 12/8  Demo of Morphing with Chimera

Structural Biology and Life Science:
1. Membrane proteins
2. Photosensory systems 
第14週
 12/15  Structural Biology and Life Science:
4. Signal transduction through G-protein
5. Two-component system 
第15週
 12/22  Group presentation in special topics:
Group 1-4 
第16週
 12/29  Group presentation in special topics:
Group 5-8 
第17週
 1/5  Group presentation in special topics:
Group 9 and 10